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1

The impact of drug-induced QT interval prolongation on drug discovery and development

Fermini, Bernard, Fossa, Anthony A.

Journal:

Nature Reviews Drug Discovery

Year:

2003

Language:

english

File:

PDF, 224 KB

english, 2003

2

The Evolving Roles of Human iPSC-Derived Cardiomyocytes in Drug Safety and Discovery

Gintant, Gary, Fermini, Bernard, Stockbridge, Norman, Strauss, David

Journal:

Year:

2017

Language:

english

File:

PDF, 694 KB

english, 2017

3

Challenges in designing and executing clinical trials in a dish studies

Fermini, Bernard, Coyne, Kevin P., Coyne, Shawn T.

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2018

Language:

english

File:

PDF, 702 KB

english, 2018

4

Leveraging genetic diversity in vitro: Evolution or revolution in cardiac safety assessment?

Fine, Eli J., Sullivan, Denise D., Nguyen, Anh H., Chal, Jerome, Hamilton, Jonathon B., Coyne, Kevin P., Coyne, Shawn T., Mobley, Sheldon L., Poe-Yamagata, Emma M., Dobric, Maja, Fermini, Bernard

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2018

Language:

english

File:

PDF, 55 KB

english, 2018

5

Sialic acid and the surface charge associated with hyperpolarization-activated, inward rectifying channels

Bernard Fermini, Richard D. Nathan

Journal:

Journal of Membrane Biology

Year:

1990

Language:

english

File:

PDF, 821 KB

english, 1990

6

Differential effect of HERG blocking agents on cardiac electrical alternans in the guinea pig

Anthony A Fossa, Todd Wisialowski, Eric Wolfgang, Ellen Wang, Michael Avery, David L Raunig, Bernard Fermini

Journal:

European Journal of Pharmacology

Year:

2004

Language:

english

File:

PDF, 501 KB

english, 2004

7

Mechanistic exploration of extended QT prolongation observed in dog safety pharmacology study

Sunny Z. Sun, Chantelle Connaughton, Amy Rosado, Michael Sutton, Jason Cordes, Pietvan der Graaf, Nick Edmunds, Bernard Fermini

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2010

Language:

english

File:

PDF, 55 KB

english, 2010

8

In vitro rat hippocampal slice model for pro-convulsion liability assessment

Xian Chen, Sunny Z. Sun, Richard Newman, Karen Tse, Gareth Waldron, Bernard Fermini, Jill Steidl-Nichols

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2010

Language:

english

File:

PDF, 49 KB

english, 2010

9

Species comparison of L-type Ca2+ currents in cardiac myocytes isolated from rat, rabbit, and non-human primate

Xian Chen, Sunny Z. Sun, Bernard Fermini

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2011

Language:

english

File:

PDF, 61 KB

english, 2011

10

Pharmacokinetic–pharmacodynamic modelling of the effect of Moxifloxacin on QTc prolongation in telemetered cynomolgus monkeys

Kenny J. Watson, William P. Gorczyca, John Umland, Ying Zhang, Xian Chen, Sunny Z. Sun, Bernard Fermini, Mark Holbrook, Piet H. Van Der Graaf

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2011

Language:

english

File:

PDF, 1.19 MB

english, 2011

11

Correlation of compound effects on GABAA Cl channels between a radioligand binding and a functional patch clamp assay

Kelly A. McKiernan, Xian Chen, Bernard Fermini, Sunny Z. Sun

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2011

Language:

english

File:

PDF, 57 KB

english, 2011

12

The use of alternate QRS measurement methods to improve detection of propafenone-induced QRS prolongation

Peter D. Harris, Stephen C. Foote, Dingzhou Li, Bernard Fermini, Jill Steidl

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2011

Language:

english

File:

PDF, 54 KB

english, 2011

13

Influence of explantation procedure on the properties of cultured neonatal rat ventricle cells

O.F. Schanne, B. Fermini, J. Hugon

Journal:

Journal of Molecular and Cellular Cardiology

Year:

1983

Language:

english

File:

PDF, 94 KB

english, 1983

14

Influence of trypsin, collagenase and mechanical agitation on the properties of cultured neonatal rat ventricle cells

B. Fermini, O.F. Schanne, J.S. Hugon

Journal:

Journal of Molecular and Cellular Cardiology

Year:

1984

Language:

english

File:

PDF, 84 KB

english, 1984

15

Development of a high-throughput functional cell based l-type calcium channel assay

Jenkinson, Stephen, Bassyouni, Asser, Hemkens, Michelle, Sun, Sunny, Kim, Sung, Fermini, Bernard, Butler, Paul

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2013

Language:

english

File:

PDF, 58 KB

english, 2013

16

Use of a guinea pig Langendorff-perfused heart model for assessing translation of cardiac sodium channel block and QRS widening in dogs

Ramirez, David S., Jenkinson, Stephen, Cordes, Jason, Rosado, Amy, Steidl-Nichols, Jill, Fermini, Bernard

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2013

Language:

english

File:

PDF, 59 KB

english, 2013

17

Use of an in vitro contractility assay to explore cardiac contractility changes observed in an in vivo cardiovascular study

Sun, Sunny Z., Harris, Peter, Flynn, Declan, Steidl-Nichols, Jill, Fermini, Bernard

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2013

Language:

english

File:

PDF, 59 KB

english, 2013

18

Evaluation of the Rubidium Efflux Assay for Preclinical Identification of hERG Blockade

Chaudhary, Khuram W., O'Neal, Janet M., Mo, Zun-Li, Fermini, Bernard, Gallavan, Robert H., Bahinski, Anthony

Journal:

Assay and Drug Development Technologies

Year:

2006

Language:

english

File:

PDF, 221 KB

english, 2006

19

Rapid and slow components of delayed rectifier current in human atrial myocytes

Wang, Z., Fermini, B., Nattel, S.

Journal:

Cardiovascular Research

Year:

1994

Language:

english

File:

PDF, 932 KB

english, 1994

20

Determinants of action potential duration in neonatal rat ventricle cells

Fermini, B., Schanne, O. F

Journal:

Cardiovascular Research

Year:

1991

Language:

english

File:

PDF, 825 KB

english, 1991

21

Sustained depolarization-induced outward current in human atrial myocytes. Evidence for a novel delayed rectifier K+ current similar to Kv1.5 cloned channel currents

Wang, Z., Fermini, B., Nattel, S.

Journal:

Circulation Research

Year:

1993

Language:

english

File:

PDF, 3.15 MB

english, 1993

22

Identity of a novel delayed rectifier current from human heart with a cloned K+ channel current.

Fedida, D., Wible, B., Wang, Z., Fermini, B., Faust, F., Nattel, S., Brown, A. M.

Journal:

Circulation Research

Year:

1993

File:

PDF, 1.60 MB

1993

23

Comparative Gene Expression Profiling in Human-Induced Pluripotent Stem Cell--Derived Cardiocytes and Human and Cynomolgus Heart Tissue

Puppala, D., Collis, L. P., Sun, S. Z., Bonato, V., Chen, X., Anson, B., Pletcher, M., Fermini, B., Engle, S. J.

Journal:

Toxicological Sciences

Year:

2013

Language:

english

File:

PDF, 698 KB

english, 2013

24

Delayed rectifier outward current and repolarization in human atrial myocytes

Wang, Z., Fermini, B., Nattel, S.

Journal:

Circulation Research

Year:

1993

Language:

english

File:

PDF, 2.14 MB

english, 1993

25

[Topics in Medicinal Chemistry] Ion Channels Volume 3 || Role of Kv7 and Cav3 Ion Channels in Pain

Fermini, Bernard, Priest, Birgit T.

Year:

2008

Language:

english

File:

PDF, 586 KB

english, 2008

26

A New Perspective in the Field of Cardiac Safety Testing through the Comprehensive In Vitro Proarrhythmia Assay Paradigm

Fermini, B., Hancox, J. C., Abi-Gerges, N., Bridgland-Taylor, M., Chaudhary, K. W., Colatsky, T., Correll, K., Crumb, W., Damiano, B., Erdemli, G., Gintant, G., Imredy, J., Koerner, J., Kramer, J., Le

Journal:

Journal of Biomolecular Screening

Year:

2015

Language:

english

File:

PDF, 851 KB

english, 2015

27

Deranged sodium to sudden death

Clancy, Colleen E., Chen-Izu, Ye, Bers, Donald M., Belardinelli, Luiz, Boyden, Penelope A., Csernoch, Laszlo, Despa, Sanda, Fermini, Bernard, Hool, Livia C., Izu, Leighton, Kass, Robert S., Lederer, W

Journal:

The Journal of Physiology

Year:

2015

Language:

english

File:

PDF, 321 KB

english, 2015

28

[Topics in Medicinal Chemistry] Ion Channels Volume 3 || On the Process of Finding Novel and Selective Sodium Channel Blockers for the Treatment of Diseases

Fermini, Bernard, Priest, Birgit T.

Year:

2008

Language:

english

File:

PDF, 558 KB

english, 2008

29

[Topics in Medicinal Chemistry] Ion Channels Volume 3 || Kv1.5 Potassium Channel Inhibitors for the Treatment and Prevention of Atrial Fibrillation

Fermini, Bernard, Priest, Birgit T.

Year:

2008

Language:

english

File:

PDF, 1.16 MB

english, 2008

30

The Comprehensive in Vitro Proarrhythmia Assay (CiPA) initiative — Update on progress

Colatsky, Thomas, Fermini, Bernard, Gintant, Gary, Pierson, Jennifer B., Sager, Philip, Sekino, Yuko, Strauss, David G., Stockbridge, Norman

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2016

Language:

english

File:

PDF, 339 KB

english, 2016

31

Computational Cardiology and Risk Stratification for Sudden Cardiac Death: One of the Grand Challenges for Cardiology in the 21 st Century

Hill, Adam P., Perry, Matthew D., Abi-Gerges, Najah, Couderc, Jean-Philippe, Fermini, Bernard, Hancox, Jules C., Knollmann, Bjorn C., Mirams, Gary R., Skinner, Jon, Zareba, Wojciech, Vandenberg, Jamie

Journal:

The Journal of Physiology

Year:

2016

Language:

english

File:

PDF, 377 KB

english, 2016

32

Amiodarone: Pharmacology, Clinical Actions, and Relationships Between Them

NATTEL, STANLEY, TALAJIC, MARIO, FERMINI, BERNARD, ROY, DENIS

Journal:

Journal of Cardiovascular Electrophysiology

Year:

1992

Language:

english

File:

PDF, 7.46 MB

english, 1992

33

Use-Dependent Effects of the Class III Antiarrhythmic Agent NE-10064 (Azimilide) on Cardiac Repolarization

Fermini, Bernard, Jurkiewicz, Nancy K., Jow, Brian, Guinosso, Peter J., Baskin, Elizabeth P., Lynch, Joseph J., Salata, Joseph J.

Journal:

Journal of Cardiovascular Pharmacology

Year:

1995

File:

PDF, 1.14 MB

1995

34

L-type calcium channel antagonism – Translation from in vitro to in vivo

Fermini, Bernard, Ramirez, David S, Sun, Sunny, Bassyouni, Asser, Hemkens, Michelle, Wisialowski, Todd, Jenkinson, Stephen

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2017

Language:

english

File:

PDF, 448 KB

english, 2017

35

[Topics in Medicinal Chemistry] Ion Channels Volume 3 || Recent Advances in Ion Channel Screening Technologies

Fermini, Bernard, Priest, Birgit T.

Year:

2008

Language:

english

File:

PDF, 390 KB

english, 2008

36

Mechanism of flecainide's rate-dependent actions on action potential duration in canine atrial tissue.

Wang, Z, Fermini, B, Nattel, S

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

1993

Language:

english

File:

PDF, 1.46 MB

english, 1993

37

Measuring kinetics and potency of hERG block for CiPA

Windley, Monique J., Abi-Gerges, Najah, Fermini, Bernard, Hancox, Jules C., Vandenberg, Jamie I., Hill, Adam P.

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2017

Language:

english

File:

PDF, 871 KB

english, 2017

38

Proarrhythmia liability assessment and the comprehensive in vitro Proarrhythmia Assay (CiPA): An industry survey on current practice

Authier, Simon, Pugsley, Michael K., Koerner, John E., Fermini, Bernard, Redfern, William S., Valentin, Jean-Pierre, Vargas, Hugo M., Leishman, Derek J., Correll, Krystle, Curtis, Michael J.

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2017

Language:

english

File:

PDF, 786 KB

english, 2017

39

Cardiac voltage-gated ion channels in safety pharmacology: Review of the landscape leading to the CiPA initiative

Huang, Hai, Pugsley, Michael K., Fermini, Bernard, Curtis, Michael J., Koerner, John, Accardi, Michael, Authier, Simon

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2017

Language:

english

File:

PDF, 1.58 MB

english, 2017

40

[Annual Reports in Medicinal Chemistry] Volume 39 || Pre-Clinical Assessment of Drug-Induced QT Interval Prolongation. Current Issues and Impact on Drug Discovery

Fermini, Bernard

Year:

2004

Language:

english

File:

PDF, 123 KB

english, 2004

41

[Topics in Medicinal Chemistry] Ion Channels Volume 3 || Pharmacological Rescue of Mutant CFTR Function for the Treatment of Cystic Fibrosis

Fermini, Bernard, Priest, Birgit T.

Year:

2008

Language:

english

File:

PDF, 898 KB

english, 2008

42

Cardiac sodium channel antagonism – Translation of preclinical in vitro assays to clinical QRS prolongation

Jenkinson, Stephen, Bassyouni, Asser, Cordes, Jason, Fermini, Bernard, Guo, Donglin, Potter, David M., Ramirez, David S., Steidl-Nichols, Jill, Sun, Sunny, Wisialowski, Todd

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2017

Language:

english

File:

PDF, 760 KB

english, 2017

43

A SPS Survey on Cardiovascular Safety Pharmacology Practices Assessing Proarrhythmia Risk in Drug Safety Testing: State of the Art Prior to Implementation of the Comprehensive In Vitro Proarrhythmia Assay (CiPA) Paradigm

Pugsley, Michael K., Fermini, Bernard, Koerner, John, Correll, Krystle, Authier, Simon, Redfern, Willian S., Valentin, Jean-Pierre, Vargas, Hugo, Leishman, Derek J., Curtis, Michael J.

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2017

Language:

english

File:

PDF, 51 KB

english, 2017

44

Successes and Challenges of Performing hERG Studies for CiPA

Windley, Monique, Abi-Gerges, Najah, Fermini, Bernard, Hancox, Jules, Vandenberg, Jamie, Hill, Adam

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2017

Language:

english

File:

PDF, 54 KB

english, 2017

45

Clinical Trials in a Dish: A Perspective on the Coming Revolution in Drug Development

Fermini, Bernard, Coyne, Shawn T., Coyne, Kevin P.

Journal:

Year:

2018

Language:

english

File:

PDF, 248 KB

english, 2018

46

Membrane resistance increases when automaticity develops in explanted rat heart cells

Schanne, O. F., Lefloch, M., Fermini, B., Ruiz-Petrich, E.

Journal:

American journal of physiology. Heart and circulatory physiology

Year:

1990

Language:

english

File:

PDF, 2.00 MB

english, 1990

47

Removal of sialic acid alters both T- and L-type calcium currents in cardiac myocytes

Fermini, B., Nathan, R. D.

Journal:

American journal of physiology. Heart and circulatory physiology

Year:

1991

Language:

english

File:

PDF, 2.12 MB

english, 1991

48

Properties of sodium and potassium currents of cultured adult human atrial myocytes

Feng, J., Li, G. R., Fermini, B., Nattel, S.

Journal:

American journal of physiology. Heart and circulatory physiology

Year:

1996

Language:

english

File:

PDF, 2.21 MB

english, 1996

49

Repolarization differences between guinea pig atrial endocardium and epicardium: evidence for a role of Ito

Wang, Z. G., Fermini, B., Nattel, S.

Journal:

American journal of physiology. Heart and circulatory physiology

Year:

1991

Language:

english

File:

PDF, 1.56 MB

english, 1991

50

Utilization of Three-Dimensional Culture for Early Morphometric and Electrophysiological Analyses of Solitary Cerebellar Neurons

Coates, P.W., Fermini, B., Strahlendorf, J.C., Strahlendorf, H.K.

Journal:

Developmental Neuroscience

Year:

1992

Language:

english

File:

PDF, 2.42 MB

english, 1992